PGT by NGS

Advanced Genetic Testing for Healthier Embryo Selection

Preimplantation Genetic Testing (PGT) using Next-Generation Sequencing (NGS) is an advanced technique used during IVF to analyze the genetic health of embryos before transfer. It helps identify chromosomal abnormalities and inherited genetic conditions, allowing the selection of the healthiest embryos for implantation.

At Bangkok Central Clinic, we use cutting-edge NGS technology to deliver highly accurate genetic insights, improving IVF success rates and reducing the risk of miscarriage or genetic disorders.

Overview

What is PGT by NGS?

PGT is an advanced genetic testing technique performed on embryos created through IVF. Using cutting-edge Next-Generation Sequencing (NGS) technology, it allows comprehensive analysis of all 23 pairs of chromosomes with exceptional precision. This helps detect abnormalities such as extra or missing chromosomes (aneuploidy), gene mutations, and structural rearrangements.

By identifying genetically normal embryos, PGT enables specialists to select those with the highest potential for successful implantation and a healthy pregnancy. This not only improves IVF success rates but also reduces the risk of miscarriage and genetic disorders.

Benefits

Benefits of PGT by NGS

  • Comprehensive genetic screening: Advanced analysis of all 23 pairs of chromosomes ensures a thorough and highly precise evaluation of embryo health.
  • Improved implantation rates: By selecting genetically healthy embryos, the chances of successful implantation are significantly enhanced.
  • Reduced miscarriage risk: Screening helps avoid the transfer of embryos with chromosomal abnormalities, lowering the risk of miscarriage.
  • Prevention of genetic disorders: Supports the selection of embryos free from certain inherited genetic conditions, promoting a healthier pregnancy.
  • High accuracy: Utilizes advanced technologies like Next-Generation Sequencing (NGS) to deliver up to 99.9% accuracy in detecting chromosomal abnormalities.
  • Better IVF outcomes: Overall, PGT improves IVF success rates, increasing the likelihood of achieving a healthy and successful pregnancy

Treatment Options

PGT Testing Options Available

PGT-A (Preimplantation Genetic Testing for Aneuploidy)

PGT-A is an advanced genetic screening technique used during IVF to evaluate embryos for chromosomal abnormalities before implantation. These abnormalities—such as extra or missing chromosomes (aneuploidy)—are one of the leading causes of failed implantation, recurrent miscarriages, and genetic conditions like Down syndrome.

During the IVF process, a few cells are carefully biopsied from the developing embryo and analyzed in a specialized laboratory. This allows doctors to identify which embryos have the correct number of chromosomes (euploid embryos) and are more likely to result in a healthy pregnancy.

By selecting chromosomally normal embryos for transfer, PGT-A helps improve implantation rates, reduce the risk of miscarriage, and enhance the overall success rates of IVF. It also supports better decision-making for patients, especially those with a history of repeated IVF failures, miscarriages, or advanced maternal age.

PGT-M (Preimplantation Genetic Testing for Monogenic Disorders)

PGT-M is recommended for individuals or couples with a known history of inherited genetic disorders. This test identifies specific gene mutations and ensures that only unaffected embryos are selected for transfer.

It is commonly used for conditions such as thalassemia, cystic fibrosis, and other inherited diseases.

PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)

PGT-SR is designed for individuals with chromosomal structural abnormalities, such as translocations or inversions. These conditions may not affect overall health but can impact fertility and increase the risk of miscarriage.

PGT-SR helps identify embryos with balanced chromosome structures, improving the chances of a healthy pregnancy.

Choosing the Right PGT Option

The most suitable PGT test depends on your medical history, genetic background, and fertility goals. Our specialists will guide you in selecting the right approach to maximize your chances of success while ensuring the safety and health of your future child.

Procedure

Step-by-Step PGT-A by NGS Process

The PGT testing process is carefully managed by experienced embryologists and fertility specialists:

  • Step 1: IVF Fertilization

    Eggs are retrieved from the ovaries and fertilized with sperm in a controlled laboratory environment to create embryos.

  • Step 2: Embryo Development

    The fertilized eggs are carefully monitored as they grow and develop into embryos over 5–6 days, reaching the blastocyst stage.

  • Step 3: Embryo Biopsy

    At the blastocyst stage, a few cells are gently and safely removed from the outer layer of the embryo. This process does not harm the embryo’s development.

  • Step 4: PGT Screening Using NGS

    The sampled cells are analyzed using advanced Next-Generation Sequencing (NGS) technology for PGT-A/PGT-M, allowing accurate assessment of chromosome number and detection of genetic abnormalities.

  • Step 5: Embryo Selection

    Based on the test results, embryos with the correct number of chromosomes (genetically normal embryos) are identified and selected for transfer.

  • Step 6: Embryo Transfer

    A healthy embryo is then transferred into the uterus, increasing the chances of successful implantation and a healthy pregnancy.

Pricing

PGT Testing Cost in Bangkok

The cost of PGT by NGS varies depending on individual treatment plans and clinical requirements.

Factors that influence cost include:

  • Number of embryos tested
  • IVF/ICSI treatment cycle
  • Type of PGT (PGT-A, PGT-M, or PGT-SR)
  • Patient’s fertility profile and medical needs

What’s included in our PGT package:

  • Embryo biopsy procedure
  • Advanced NGS genetic testing
  • Laboratory analysis and reporting
  • Genetic counseling and result interpretation
  • Support in embryo selection for transfer

We offer transparent pricing and comprehensive packages to help you plan your treatment with confidence.

Outcome

What Affects PGT Success Rates?

Success with PGT depends on multiple factors:

  • Maternal age: Younger women generally have better egg quality, which increases the likelihood of developing healthy, chromosomally normal embryos.
  • Embryo quality: High-quality embryos have a greater potential for successful implantation and healthy development.
  • Number of embryos tested: A higher number of embryos allows for better selection, improving the chances of identifying a genetically normal embryo.
  • Underlying fertility conditions: Individual medical history and fertility-related conditions can influence overall outcomes and treatment success.
  • Laboratory standards: Advanced laboratory technology and the expertise of skilled embryologists play a critical role in ensuring accurate testing and optimal embryo handling.

At Bangkok Central Clinic, we combine state-of-the-art technology with an experienced fertility team to deliver outcomes comparable to leading international fertility centers, ensuring patients receive the highest standard of care throughout their journey.

Common Queries

Frequently Asked Questions

What is PGT and why is it used in IVF?

PGT (Preimplantation Genetic Testing) is used during IVF to screen embryos for genetic abnormalities before transfer. It helps select the healthiest embryos, improving the chances of a successful pregnancy and reducing the risk of miscarriage or genetic disorders.

What is the difference between PGT-A, PGT-M, and PGT-SR?

PGT-A checks for chromosomal abnormalities, PGT-M tests for specific inherited genetic diseases, and PGT-SR is used for structural chromosome issues like translocations. The right test depends on your medical and family history.

Who should consider PGT testing?

PGT is recommended for couples with a history of genetic disorders, recurrent miscarriages, failed IVF cycles, or advanced maternal age. It is also useful for those who want to increase and improves their chances of a healthy pregnancy and family balancing.

Does PGT guarantee a successful pregnancy?

PGT improves & increase the chances of success by selecting genetically healthy embryos and reducing the risk of implantation failure or miscarriage.

Is the embryo biopsy safe?

Embryo biopsy is a safe and commonly used procedure when performed by experienced embryologists. Only a few cells are removed from the embryo, and this does not affect its ability to develop normally.

Enhance IVF Success with Advanced Embryo Screening

PGT by NGS offers clarity, confidence, and improved outcomes in IVF treatment. By selecting genetically healthy embryos, you take a significant step toward achieving a successful pregnancy.

© 2026 Bankok Central Clinic IVF . All rights reserved.

Scroll to Top